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KMID : 0858620010050010068
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Korean Journal of Audiology
2001 Volume.5 No. 1 p.68 ~ p.71
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A Case of Sensorineural Hearing Loss due to Chloroquine Therapy for the Patient of Malaria
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고철하/Cheol Ha Go
안상준/김태운/양철민/Sang Jun Ahn/Tae Woon Kim/Cheol Min Yang
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Abstract
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The chloroquine, a synthetic quinolone derivative, is used in low dosages in malarial prophylaxis and in the treatment of malaria. It is also used extensively in the treatment of active rheumatoid arthritis and in some collagen diseases such as
discoid
and systemic lupus erythematosus. Chloroquine is related chemically to quinine and, hense, has been suspected of being an ototoxic drug. The characteristics of the ototoxity caused by the chloroquine begins early at high frequency by the
reversible,
symmetrical, bilateral Sensorineural Hearing Loss. Stopping chloroquine at first sign ultra-high frequency audiomentry and Auditory Brainstem Response sign of ototoxicity and promptly instituting therapy are essential for possible early recovery
of
a
potentially permanent cochlerovestibular insult. The occurrence of permanent sensorineural hearing loss for the Chloroquine has rarely been reported in the literature yet. So, we present this case with a review of literature.
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